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Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection

Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 404-415 doi: 10.1007/s11684-021-0834-9

Abstract: Although various strategies have been used to study anti-ZIKV agents, approved drugs or vaccines forRepurposing clinically approved drugs could be an effective approach to quickly respond to an emergencyThe well-established safety profiles and optimal dosage of these clinically approved drugs could providefocuses on the recent research and development of agents against ZIKV infection by repurposing clinical drugs

Keywords： Zika virus     clinical drugs     ZIKV inhibitors     antivirals     repurposing    

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Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)

Frontiers of Medicine doi: 10.1007/s11684-023-1037-3

Abstract: So far, a few small-molecule antiviral drugs, including nirmatrelvir–ritonavir (Paxlovid), remdesivirTo date, four domestically developed oral anti-COVID-19 drugs have been granted conditional market approvalThese drugs include azvudine, simnotrelvir–ritonavir (Xiannuoxin), leritrelvir, and mindeudesivir (VV116understanding and highlight the potential widespread application of China’s homegrown anti-COVID-19 drugs

Keywords： COVID-19     antiviral drugs     mindeudesivir    

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Discovery and development of synthetic tricyclic pyrroloquinone (TPQ) alkaloid analogs for human cancer therapy

Wei Wang,Bhavitavya Nijampatnam,Sadanandan E. Velu,Ruiwen Zhang

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 1,   Pages 1-15 doi: 10.1007/s11705-016-1562-6

Abstract: their derivatives represent a rich source for the discovery and development of new cancer therapeutic drugsBioactive components derived from natural sources including marine compounds have been shown to be effective

Keywords： synthesis     marine drugs     tricyclic pyrroloquinone alkaloid     cancer therapy     MDM2     p53    

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Occurrence, distribution and risk assessment of abused drugs and their metabolites in a typical urban

Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 4, doi: 10.1007/s11783-019-1140-5

Abstract:

We developed a method for determining 11 abused drugs in water and

METH and EPH were the dominant drugs in water

Abuse drugs in Beiyunhe River were mainly from

Abused drugs in the water would not impair the

Keywords： Drugs of abuse     Occurrence     Distribution     Urban river     Environmental risk    

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Management strategies of marine food resources under multiple stressors with particular reference ofthe Yellow Sea large marine ecosystem

Qisheng TANG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 1,   Pages 85-90 doi: 10.15302/J-FASE-2014021

Abstract:

In this study two main management strategies are discussed: one is to develop resource conservation-based capture fisheries, and the other is to develop environmentally friendly aquaculture. During the resource recovery period, the development of environmentally friendly aquaculture should be encouraged, especially in integrated multi-trophic aquaculture, which is adaptive, efficient and sustainable. For future development and better understanding the ecosystem, it is necessary to further strengthen basic research.

Keywords： marine     ecosystem     management strategies     food resources     Yellow Sea    

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The Sustainable Exploitation of Marine Fish Resources and the Research Directions of Science and Technologyfor Marine Fish

Lin Haoran

Strategic Study of CAE 2003, Volume 5, Issue 3,   Pages 27-30

Abstract:

The implementation of proliferation and culture of marine fishes is the fundamental measure and effectiveavenue for the reasonable and sustainable exploitation of marine fish resources.Therefore, the establishment and development of modern techniques for the proliferation and culture of marinefishes is one of the important research areas in the marine biotechnology.immunology and the molecular biology are the theoretical basis of the proliferation and culture in marine

Keywords： marine fish resource     sustainable exploitation proliferation and culture of marine fish     science and technologyfor marine fish     marine biotechnology    

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Diversity and distribution of proteorhodopsin-containing microorganisms in marine environments

Bo WEI

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 1,   Pages 98-106 doi: 10.1007/s11783-010-0278-y

Abstract: shown that PR-containing microorganisms are widespread and compose a large proportion of the biomass in marineecological role of PR will help clarify the effect of the global flow of energy and the carbon cycle on marineProteorhodopsin (GDDP), as a tool for analyzing the diversity and distribution of PR-containing microorganisms in marine

Keywords： proteorhodopsin (PR)     microorganism community     diversity     marine environments    

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Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 815-826 doi: 10.1007/s11684-021-0891-0

Abstract: Oral drugs such as ibrutinib play an important role in the treatment of mature B-cell lymphoma (BCL)Hematology, Chinese Medical Association conducted an extensive discussion and reached a consensus on oral drugsfor Chinese BCL patients on the basis of the current application status of oral drugs in China, combinedThis consensus reviewed the application of oral drugs in the treatment of BCL and the latest researchand provided appropriate recommendations on the use of oral drugs for indolent or aggressive BCL patients

Keywords： B-cell lymphoma     oral drug     targeted therapy     immunotherapy     COVID-19 pandemic    

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Demands and challenges for construction of marine infrastructures in China

Huajun LI; Yong LIU; Bingchen LIANG; Fushun LIU; Guoxiang WU; Junfeng DU; Huimin HOU; Aijun LI; Luming SHI

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 5,   Pages 551-563 doi: 10.1007/s11709-022-0839-8

Abstract: They provide core support for exploitation and utilization of marine space, resources, and energy.Thus, marine infrastructures are vital to a nation’s economic sustainable development.utilization of marine space, 3) marine transportation infrastructure interconnection, 4) ocean clean, and 6) marine infrastructure operation safety and maintenance.Finally, perspectives on future directions of ocean utilization and marine infrastructure construction

Keywords： marine infrastructures     ocean engineering     exploitation of marine resource     coastal development     emergingmarine industries     technological challenges    

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Sensitivity analysis of the deterioration of concrete strength in marine environment to multiple corrosive

Frontiers of Structural and Civil Engineering 2023, Volume 17, Issue 2,   Pages 175-190 doi: 10.1007/s11709-021-0791-z

Abstract: plays a crucial role in the change of its mechanical properties under multi-ion interaction in the marine

Keywords： sensitivity analysis     concrete strength     corrosion deterioration     multi-ion interaction     marine environment    

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nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic acid drugs

Vaibhav Mundra, Ram I. Mahato

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 387-404 doi: 10.1007/s11705-014-1457-3

Abstract: challenges in developing efficient and target specific delivery systems of small molecule and nucleic acid drugs

Keywords： nanocarrier     cellular uptake     endosomal release     nucleic acid drug    

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Hormesis-like growth and photosynthetic physiology of marine diatom Bohlin exposed to polystyrene microplastics

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 1,   Pages 2-2 doi: 10.1007/s11783-021-1436-0

Abstract:

• Polystyrene microplastic caused hormesis-like effects in Phaeodactylum tricornutum.

Keywords： Microplastics     Marine microalgae     Phaeodactylum tricornutum Bohlin     Growth     Photosynthetic pigments    

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Study on Development Strategy for Blue Marine Living Resources

Task Force for the Study on Development Strategy of China’s Marine Engineering and Technology LivingMarine Resource Research Group

Strategic Study of CAE 2016, Volume 18, Issue 2,   Pages 32-40 doi: 10.15302/J-SSCAE-2016.02.004a

Abstract:

To improve China's development capacity of living marine resources and promote the constructionconsultation project in 2011, which is called "Strategic Study on the Development of China Living Marinemaritime resources conservation, deep sea fishery, seafood quality safety processing and logistics, marineconservation, expansion and high-technology, for multi-dimensional developing and utilizing living marineThree strategic objectives and tasks for advancing blue marine bio-industry were proposed, including

Keywords： blue marine     living marine resource development     development strategy     special research and development    

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Development Strategy for Marine Scientific Equipment and Technologies

Dong Sheng, Liao Zhenkun, Yu Liwei, Li Huajun

Strategic Study of CAE 2023, Volume 25, Issue 3,   Pages 33-41 doi: 10.15302/J-SSCAE-2023.03.004

Abstract:

Marine research equipment is critical for the development of marine sciencerecent years, China has made breakthroughs regarding the independent research and development of marineIn this paper, the current status of the marine research equipment is reviewed, including researchvessels, underwater vehicles, buoys, marine sensors, and marine observation networks.The problems encountered in the technical development of China’s marine research equipment are

Keywords： marine scientific research     deep-sea equipment     polar marine equipment     marine observation system     intellectualization    

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Marine Biotechnology and Sustainable Development of Marine Life Resources

Xu Xun

Strategic Study of CAE 2000, Volume 2, Issue 8,   Pages 40-42

Abstract: The article deals with the significance of the application of molecular biology to marine living resourcesAs an example of applying the modern methods of gene engineering to marine culture, the work on white

The most exiting prospects of marine biotechnology are in its potential of discovering new pharmaceutics

Keywords： marine biotechnology     shrimp virus     deep sea genetic resourse    

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Title Author Date Type Operation

Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection

Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang

Journal Article

Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)

Journal Article

Discovery and development of synthetic tricyclic pyrroloquinone (TPQ) alkaloid analogs for human cancer therapy

Wei Wang,Bhavitavya Nijampatnam,Sadanandan E. Velu,Ruiwen Zhang

Journal Article

Occurrence, distribution and risk assessment of abused drugs and their metabolites in a typical urban

Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu

Journal Article

Management strategies of marine food resources under multiple stressors with particular reference ofthe Yellow Sea large marine ecosystem

Qisheng TANG

Journal Article

The Sustainable Exploitation of Marine Fish Resources and the Research Directions of Science and Technologyfor Marine Fish

Lin Haoran

Journal Article

Diversity and distribution of proteorhodopsin-containing microorganisms in marine environments

Bo WEI

Journal Article

Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Journal Article

Demands and challenges for construction of marine infrastructures in China

Huajun LI; Yong LIU; Bingchen LIANG; Fushun LIU; Guoxiang WU; Junfeng DU; Huimin HOU; Aijun LI; Luming SHI

Journal Article

Sensitivity analysis of the deterioration of concrete strength in marine environment to multiple corrosive

Journal Article

nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic acid drugs

Vaibhav Mundra, Ram I. Mahato

Journal Article

Hormesis-like growth and photosynthetic physiology of marine diatom Bohlin exposed to polystyrene microplastics

Journal Article

Study on Development Strategy for Blue Marine Living Resources

Task Force for the Study on Development Strategy of China’s Marine Engineering and Technology LivingMarine Resource Research Group

Journal Article

Development Strategy for Marine Scientific Equipment and Technologies

Dong Sheng, Liao Zhenkun, Yu Liwei, Li Huajun

Journal Article

Marine Biotechnology and Sustainable Development of Marine Life Resources

Xu Xun

Journal Article